Transforming biology: from molecules to organisms
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Data
- all essential data is freely available
- enabling LML: automated curation & embedding
Compute
- compute power is in place already
- enabling LML: optimisation for exascale and quantum
Robotics
- globally unique capability
- enabling LML: complete automation of biological experiments
MAIC meta-analysis
\[\begin{matrix} w_{j}^{L} = \sqrt{\frac{\sum g_{i} \in L_{j}s_{i}}{n_{j}}} \\ \end{matrix}\]
MAIC meta-analysis
RECOVERY
- Peter Horby, University of Oxford
- Martin Landray, University of Oxford
- Richard Haynes, University of Oxford
Edinburgh
- Lee Murphy
- Angie Fawkes
- Nicola Wrobel
Glasgow
- Emma Thomson
- Toni Ho
GenOMICC Investigators
Erola Pairo-Castineira, Sara Clohisey, Lucija Klaric, Andrew D. Bretherick, Konrad Rawlik*, Dorota Pasko, Susan Walker, Nick Parkinson, Max Head Fourman, Clark D. Russell, James Furniss, Anne Richmond, Elvina Gountouna, Nicola Wrobel, David Harrison, Bo Wang, Yang Wu, Alison Meynert, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Loukas Moutsianas, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Graeme Grimes, Rupert Beale, Jonathan Millar, Barbara Shih, Sean Keating, Marie Zechner, Chris Haley, David J. Porteous, Caroline Hayward, Jian Yang, Julian Knight, Charlotte Summers, Manu Shankar-Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Shona C. Moore, Charles Hinds, Peter Horby, Alistair Nichol, David Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, Timothy Walsh, Alex Pereira, Alessandra Renieri, The GenOMICC Investigators, The ISARIC4C Investigators, The COVID-19 Human Genetics Initiative, 23andMe Investigators, BRACOVID Investigators, Gen-COVID Investigators, Xia Shen, Chris P. Ponting, Angie Fawkes, Albert Tenesa, Mark Caulfield, Richard Scott, Kathy Rowan, Lee Murphy, Peter J. M. Openshaw, Malcolm G. Semple, Andrew Law, Veronique Vitart, James F. Wilson & J. Kenneth Baillie.
Funders
- Baillie Gifford
- Sepsis Research (Fiona Elizabeth Agnew Trust)
- UKRI
- Wellcome
- Intensive Care Society
RECOVERY
- Peter Horby, University of Oxford
- Martin Landray, University of Oxford
- Richard Haynes, University of Oxford
Baillie Gifford Pandemic Science Hub
- Kev Dhaliwal
GenOMICC Investigators
Erola Pairo-Castineira*, Sara Clohisey*, Lucija Klaric*, Andrew D. Bretherick*, Konrad Rawlik*, Dorota Pasko, Susan Walker, Nick Parkinson, Max Head Fourman, Clark D. Russell, James Furniss, Anne Richmond, Elvina Gountouna, Nicola Wrobel, David Harrison, Bo Wang, Yang Wu, Alison Meynert, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Loukas Moutsianas, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Graeme Grimes, Rupert Beale, Jonathan Millar, Barbara Shih, Sean Keating, Marie Zechner, Chris Haley, David J. Porteous, Caroline Hayward, Jian Yang, Julian Knight, Charlotte Summers, Manu Shankar-Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Shona C. Moore, Charles Hinds, Peter Horby, Alistair Nichol, David Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, Timothy Walsh, Alex Pereira, Alessandra Renieri, The GenOMICC Investigators, The ISARIC4C Investigators, The COVID-19 Human Genetics Initiative, 23andMe Investigators, BRACOVID Investigators, Gen-COVID Investigators, Xia Shen, Chris P. Ponting, Angie Fawkes, Albert Tenesa, Mark Caulfield, Richard Scott, Kathy Rowan, Lee Murphy, Peter J. M. Openshaw, Malcolm G. Semple, Andrew Law, Veronique Vitart, James F. Wilson & J. Kenneth Baillie.
ISARIC4C
- Emma Thompson, University of Glasgow
- Judith Breuer, University College London
- Antoinia Ho, University of Glasgow
- Calum Semple, University of Liverpool
- Miranda Odam, University of Edinburgh
- Bernadette Gallacher, University of Edinburgh
- Primmy Chikowore, University of Edinburgh
- Konrad Rawlik, University of Edinburgh
UKHSA
- Meera Chand
- Maria Zambon
Baillie Gifford Pandemic Science Hub
- Kev Dhaliwal
GenOMICC Investigators
Erola Pairo-Castineira, Sara Clohisey, Lucija Klaric, Andrew D. Bretherick, Konrad Rawlik*, Dorota Pasko, Susan Walker, Nick Parkinson, Max Head Fourman, Clark D. Russell, James Furniss, Anne Richmond, Elvina Gountouna, Nicola Wrobel, David Harrison, Bo Wang, Yang Wu, Alison Meynert, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Loukas Moutsianas, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Graeme Grimes, Rupert Beale, Jonathan Millar, Barbara Shih, Sean Keating, Marie Zechner, Chris Haley, David J. Porteous, Caroline Hayward, Jian Yang, Julian Knight, Charlotte Summers, Manu Shankar-Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Shona C. Moore, Charles Hinds, Peter Horby, Alistair Nichol, David Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, Timothy Walsh, Alex Pereira, Alessandra Renieri, The GenOMICC Investigators, The ISARIC4C Investigators, The COVID-19 Human Genetics Initiative, 23andMe Investigators, BRACOVID Investigators, Gen-COVID Investigators, Xia Shen, Chris P. Ponting, Angie Fawkes, Albert Tenesa, Mark Caulfield, Richard Scott, Kathy Rowan, Lee Murphy, Peter J. M. Openshaw, Malcolm G. Semple, Andrew Law, Veronique Vitart, James F. Wilson & J. Kenneth Baillie.
Barts Health NHS Trust, London, UK
D Collier ( PI ), S Wood ( Lead Nurse ), A Zak ( Lead Nurse ), C Borra, M Matharu, P May, Z Alldis, O Mitchelmore, R Bowles, A Easthorpe, F Bibi, I Lancoma-Malcolm, J Gurasashvili, J Pheby, J Shiel, M Bolton, M Patel, M Taylor, O Zongo, P Ebano, P Harding, R Astin-Chamberlain, Y Choudhury, A Cox, D Kallon, M Burton, R Hall, S Blowes, Z Prime, J Biddle, O Prysyazhna, T Newman, C Tierney, J Kassam.
Guys and St Thomas’ Hospital, London, UK
M Shankar-Hari ( PI ), M Ostermann ( Co-PI ), S Campos ( Lead Nurse ), A Bociek, R Lim, N Grau, T O Jones, C Whitton, M Marotti, G Arbane.
James Cook University Hospital, Middlesburgh, UK
S. Bonner ( PI ), K Hugill, J Reid.
The Royal Liverpool University Hospital, Liverpool, UK
I Welters ( PI ), V Waugh ( Lead Nurse ), K Williams, D Shaw, J Fernandez Roman, M Lopez Martinez, E Johnson, A Waite, B Johnson, O Hamilton, S Mulla.
King’s College Hospital, London, UK
M McPhail ( PI ), J Smith.
Royal Infirmary of Edinburgh, Edinburgh, UK
J K Baillie ( PI ), L Barclay ( Lead Nurse ), D Hope, C McCulloch, L McQuillan, S Clark, J Singleton, K Priestley, N Rea, M Callaghan, R Campbell, G Andrew, L Marshall.
John Radcliffe Hospital, Oxford, UK
S McKechnie ( PI ), P Hutton ( Lead Nurse ), A Bashyal, N Davidson.
Addenbrooke’s Hospital, Cambridge, UK
C Summers ( PI ), P Polgarova ( Lead Nurse ), K Stroud, N Pathan, K Elston, S Agrawal.
Morriston Hospital, Swansea, UK
C Battle ( PI ), L Newey ( Co-PI ), T Rees ( Lead Nurse ), R Harford, E Brinkworth, M Williams, C Murphy.
Ashford and St Peter’s Hospital, Surrey, UK
I White ( PI ), M Croft ( Lead Nurse ).
Royal Stoke University Hospital, Staffordshire, UK
N Bandla ( PI ), M Gellamucho ( Lead Nurse ), J Tomlinson, H Turner, M Davies, A Quinn, I Hussain, C Thompson, H Parker, R Bradley, R Griffiths.
Queen Elizabeth Hospital, Birmingham, UK
J. Scriven ( PI ), J Gill.
Glasgow Royal Infirmary, Glasgow, UK
A Puxty ( PI ), S Cathcart ( Lead Nurse ), D Salutous, L Turner, K Duffy, K Puxty.
Kingston Hospital, Surrey, UK
A Joseph ( PI ), R Hermangrant ( Lead Nurse ), R Simms, A Swain, A Naranjo, R Crowe, K Sollesta, A Loveridge, D Baptista, E Morino.
The Tunbridge Wells Hospital and Maidstone Hospital, Kent, UK
M Davey ( PI ), D Golden ( Co-PI ), J Jones( Lead Nurse ).
North Middlesex University Hospital NHS trust, London, UK
J Moreno Cuesta ( PI ), A Haldeos ( Co-PI ), D Bakthavatsalam ( Lead Nurse ), R Vincent ( Lead Nurse ), M Elhassan, K Xavier, A Ganesan, D Purohit M Abdelrazik.
Bradford Royal Infirmary, Bradford, UK
J Morgan ( PI ), L Akeroyd ( Lead Nurse ), S Bano, D Warren, M Bromley, K Sellick, L Gurr, B Wilkinson, V Nagarajan, P Szedlak.
Blackpool Victoria Hospital, Blackpool, UK
J Cupitt ( PI ), E Stoddard ( Lead Nurse ), L Benham ( Lead Nurse ), S Preston, N Slawson, Z Bradshaw, J brown, M Caswell, S Melling.
Countess of Chester Hospital, Chester, UK
P Bamford ( PI ), M Faulkner ( Lead Nurse ), K Cawley ( Lead Nurse ), H Jeffrey ( Lead Nurse ), E London, H Sainsbury, I Nagra, F Nasir, Ce Dunmore, R Jones, A Abraheem, M Al-Moasseb, R Girach.
Wythenshawe Hospital, Manchester, UK
C Brantwood ( PI ), P Alexander ( Co-PI ), J Bradley-Potts ( Lead Nurse ), S Allen, T Felton.
St George’s Hospital, London, UK
S Manna ( PI ), S Farnell-Ward ( PI ), S Leaver ( Co-PI ), J Queiroz ( Lead Nurse ), E Maccacari ( Lead Nurse ), D Dawson, C Castro Delgado, R Pepermans Saluzzio, O Ezeobu, L Ding, C Sicat, R Kanu, G Durrant, J Texeira, A Harrison, T Samakomva.
Good Hope Hospital, Birmingham, UK
J Scriven ( PI ), H Willis, B Hopkins ( Lead Nurse ), L Thrasyvoulou ( Lead Nurse ).
Stepping Hill Hospital, Stockport, UK
M Jackson ( PI ), A Zaki ( Co-PI ), C Tibke ( Lead Nurse ), S Bennett, W Woodyatt, A Kent, E Goodwin.
Manchester Royal Infirmary, Manchester, UK
C Brandwood ( PI ), R Clark, L Smith.
Royal Alexandra Hospital, Paisley, UK
K Rooney ( PI ), N Thomson ( Lead Nurse ), N Rodden ( Lead Nurse ), E Hughes ( Lead Nurse ), D McGlynn ( Lead Nurse ), C Clark ( Lead Nurse ), P Clark ( Lead Nurse ), L Abel ( Lead Nurse ), R Sundaram, L Gemmell, M Brett, J Hornsby, P MacGoey, R Price, B Digby, P O’Neil, P McConnell, P Henderson.
Queen Elizabeth University Hospital, Glasgow, UK
S Henderson ( PI ), M Sim ( Co-PI ), S Kennedy-Hay ( Lead Nurse ), C McParland, L Rooney, N Baxter.
Queen Alexandra Hospital, Portsmouth, UK
D Pogson ( PI ), S Rose ( Lead Nurse ), Z Daly, L Brimfield.
BHRUT (Barking Havering) - Queens Hospital and King George Hospital,
Essex, UK
M K Phull ( PI ), M Hussain ( Co-PI ), T Pogreban ( Lead Nurse ), L Rosaroso ( Lead Nurse ), E Salciute L Grauslyte.
University College Hospital, London, UK
D Brealey ( PI ), E Wraith ( Co-PI ), N MacCallum ( Co-PI ), G Bercades ( Lead Nurse ), I Hass, D Smyth, A Reyes, G Martir.
Royal Victoria Infirmary, Newcastle Upon Tyne, UK
I D Clement ( PI ), K Webster ( Lead Nurse ), C Hays, A Gulati.
Western Sussex Hospitals, West Sussex, UK
L Hodgson ( PI ), M Margarson ( Co-PI ), R Gomez ( Lead Nurse ), Y Baird ( Lead Nurse ), Y Thirlwall, L Folkes, A Butler, E Meadows, S Moore, D Raynard, H Fox, L Riddles, K King, S Kimber, G Hobden, A McCarthy, V Cannons, I Balagosa, I Chadbourn, A Gardner.
Salford Royal Hospital, Manchester, UK
D Horner ( PI ), D McLaughlanv ( Lead Nurse ), B Charles ( Lead Nurse ), N Proudfoot, T Marsden, L Mc Morrow, B Blackledge, J Pendlebury, A Harvey, E Apetri, C Basikolo, L Catlow, R Doonan, K Knowles, S Lee, D Lomas, C Lyons, J Perez, M Poulaka, M Slaughter, K Slevin, M Taylor, V Thomas, D Walker, J Harris.
The Royal Oldham Hospital, Manchester, UK
A Drummond ( PI ), R Tully ( Co-PI ), J Dearden ( Lead Nurse ), J Philbin, S Munt, C Rishton, G O’Connor, M Mulcahy, E Dobson, J Cuttler, M Edward.
Pinderfields General Hospital, Wakefield, UK
A Rose ( PI ), B Sloan ( Co-PI ), S Buckley ( Lead Nurse ), H Brooke, E Smithson, R Charlesworth, R Sandu, M Thirumaran, V Wagstaff, J Cebrian Suarez.
Basildon Hospital, Basildon, UK
A Kaliappan ( PI ), M Vertue ( Lead Nurse ), A Nicholson, J Riches, A Solesbury, L Kittridge, M Forsey, G Maloney.
University Hospital of Wales, Cardiff, UK
J Cole ( PI ), M Davies, R Davies, H Hill, E Thomas, A Williams, D Duffin, B Player.
Broomfield Hospital, Chelmsford, UK
J Radhakrishnan ( PI ), S Gibson, A Lyle, F McNeela.
Royal Brompton Hospital, London, UK
B Patel ( PI ), M Gummadi ( Lead Nurse ), G Sloane, N Dormand, S Salmi, Z Farzad, D Cristiano, K Liyanage, V Thwaites, M Varghese.
Nottingham University Hospital, Nottingham, UK
M Meredith ( PI ).
Royal Hallamshire Hospital and Northern General Hospital, Sheffield, UK
G Mills ( PI ), J Willson ( Lead Nurse ), K Harrington, B Lenagh, K Cawthron, S Masuko, A Raithatha, K Bauchmuller, N Ahmad, J Barker, Y Jackson, F Kibutu, S Bird.
Royal Hampshire County Hospital, Hampshire, UK
G Watson ( PI ), J Martin ( Lead Nurse ), E Bevan, C Wrey Brown, D Trodd.
Queens Hospital Burton, Burton-On-Trent, UK
K English ( PI ), G Bell ( Lead Nurse ), L Wilcox ( Lead Nurse ), A Katary.
New Cross Hospital, Wolverhampton, UK
S Gopal ( PI ), V Lake ( Lead Nurse ), N Harris ( Lead Nurse ), S Metherell, E Radford.
Heartlands Hospital, Birmingham, UK
J Scriven ( PI ), F Moore, H Bancroft, J Daglish, M Sangombe, M Carmody, J Rhodes, M Bellamy.
Walsall Manor Hospital, Walsall, UK
A Garg ( PI ), A Kuravi ( Co-PI ), E Virgilio ( Lead Nurse ), P Ranga ( Lead Nurse ), J Butler ( Lead Nurse ), L Botfield, C Dexter, J Fletcher.
Stoke Mandeville Hospital, Buckinghamshire, UK
P Shanmugasundaram ( PI ), G Hambrook ( Lead Nurse ), I Burn, K Manso, D Thornton, J Tebbutt, R Penn.
Sandwell General Hospital, Birmingham, UK
J Hulme ( PI ), S Hussain ( Lead Nurse ), Z Maqsood, S Joseph, J Colley , A Hayes, C Ahmed, R Haque, S Clamp, R Kumar, M Purewal, B Baines.
Royal Berkshire NHS Foundation Trust, Berkshire, UK
M Frise ( PI ), N Jaques, H Coles ( Lead Nurse ), J Caterson, S Gurung Rai, M Brunton, E Tilney, L Keating, A Walden.
Charing Cross Hospital, St Mary’s Hospital and Hammersmith Hospital,
London, UK
D Antcliffe ( PI ), A Gordon ( Co-PI ), M Templeton ( Lead Nurse ), R Rojo, D Banach, S Sousa Arias, Z Fernandez, P Coghlan.
Dumfries and Galloway Royal Infirmary, Dumfries, UK
D Williams ( PI ), C Jardine ( Lead Nurse ).
Bristol Royal Infirmary, Bristol, UK
J Bewley ( PI ), K Sweet ( Lead Nurse ), L Grimmer, R Johnson, Z Garland, B Gumbrill.
Royal Sussex County Hospital, Brighton, UK
C Phillips ( PI ), L Ortiz-Ruiz de Gordoa ( Co-PI ), E Peasgood.
Whiston Hospital, Prescot, UK
A Tridente ( PI ), K Shuker ( Lead Nurse ) S Greer.
Royal Glamorgan Hospital, Cardiff, UK
C Lynch ( PI ), C Pothecary ( Lead Nurse ), L Roche ( Lead Nurse ), B Deacon ( Lead Nurse ), K Turner, J Singh, G Sera Howe.
King’s Mill Hospital, Nottingham, UK
P Paul ( PI ), M Gill ( Lead Nurse ), I Wynter, V Ratnam, S Shelton.
Fairfield General Hospital, Bury, UK
J Naisbitt ( PI ), J Melville.
Western General Hospital, Edinburgh, UK
R Baruah ( PI ), S Morrison ( Lead Nurse ).
Northwick Park Hospital, London, UK
A McGregor ( PI ), V Parris ( Co-PI ), M Mpelembue ( Lead Nurse ), S Srikaran, C Dennis, A Sukha.
Royal Preston Hospital, Preston, UK
A Williams ( PI ), M Verlande.
Royal Derby Hospital, Derby, UK
K Holding ( PI ), K Riches ( Lead Nurse ), C Downes, C Swan.
Sunderland Royal Hospital, Sunderland, UK
A Rostron ( PI ), A Roy ( Co-PI ), L Woods ( Lead Nurse ), S Cornell, F Wakinshaw.
Royal Surrey County Hospital, Guildford, UK
B Creagh-Brown ( PI ), H Blackman ( Lead Nurse ), A Salberg ( Lead Nurse ), E Smith, S Donlon, S Mtuwa, N Michalak-Glinska, S Stone, C Beazley, V Pristopan.
Derriford Hospital, Plymouth, UK
N Nikitas ( PI ), L Lankester ( Lead Nurse ), C Wells.
Croydon University Hospital, Croydon, UK
A S Raj ( PI ), K Fletcher ( Co-PI ), R Khade ( Lead Nurse ), G Tsinaslanidis.
Victoria Hospital, Kirkcaldy, UK
M McMahon ( PI ), S Fowler ( Lead Nurse ), A McGregor ( Lead Nurse ), T Coventry.
Milton Keynes University Hospital, Milton Keynes, UK
R Stewart ( PI ), L Wren ( Lead Nurse ), E Mwaura ( Lead Nurse ), L Mew ( Lead Nurse ), A Rose ( Lead Nurse ), D Scaletta, F Williams.
Barnsley Hospital, Barnsley, UK
K Inweregbu ( PI ), A Nicholson ( Lead Nurse ), N Lancaster, M Cunningham, A Daniels, L Harrison, S Hope, S Jones, A Crew, G Wray, J Matthews, R Crawley.
York Hospital, York, UK
J Carter ( PI ), I Birkinshaw ( Lead Nurse ), J Ingham, Z Scott, K Howard, R Joy, S Roche.
University Hospital of North Tees, Stockton on Tees, UK
M Clark ( PI ), S Purvis ( Lead Nurse ).
University Hospital Wishaw, Wishaw, UK
A Morrison ( PI ), D Strachan ( Co-PI ), M Taylor ( Lead Nurse ), S Clements, K Black.
Whittington Hospital, London, UK
C Parmar ( PI ), A Altabaibeh ( Co-PI ), K Simpson ( Lead Nurse ), L Mostoles ( Lead Nurse ), K Gilbert, L Ma, A Alvaro.
Southmead Hospital, Bristol, UK
M Thomas ( PI ), B Faulkner ( Lead Nurse ), R Worner, K Hayes, E Gendall, H Blakemore, B Borislavova, E Goff.
The Royal Papworth Hospital, Cambridge, UK
A Vuylsteke ( PI ), L Mwaura ( Co-PI ), J Zamikula ( Lead Nurse ), L Garner, A Mitchell, S Mepham, L Cagova, A Fofano, H Holcombe, K Praman.
Royal Gwent Hospital, Newport, UK
T Szakmany ( PI ), A E Heron ( Lead Nurse ), S Cherian ( Lead Nurse ), S Cutler, A Roynon-Reed.
Norfolk and Norwich University hospital (NNUH), Norwich, UK
G Randell ( PI ), K Convery ( Lead Nurse ), K Stammers D Fottrell-Gould, L Hudig, J Keshet-price.
Great Ormond St Hospital and UCL Great Ormond St Institute of Child
Health NIHR Biomedical Research Centre, London, UK
M Peters ( PI ), L O’Neill ( Lead Nurse ), S Ray, H Belfield, T McHugh, G Jones, O Akinkugbe, A Tomas, E Abaleke, E Beech, H Meghari, S Yussuf, A Bamford.
Airedale General Hospital, Keighley, UK
B Hairsine ( PI ), E Dooks ( Lead Nurse ), F Farquhar ( Lead Nurse ), S Packham ( Lead Nurse ), H Bates ( Lead Nurse ), C McParland, L Armstrong.
Aberdeen Royal Infirmary, Aberdeen, UK
C Kaye ( PI ), A Allan ( Lead Nurse ), J Medhora, J Liew, A Botello, F Anderson.
Southampton General Hospital, Southampton, UK
R Cusack ( PI ), H Golding ( Lead Nurse ), K Prager, T Williams, S Leggett, K Golder, M Male, O Jones, K Criste, M Marani.
Russell’s Hall Hospital, Dudley, UK
Dr. Anumakonda ( PI ), V Amin ( Co-PI ), K Karthik ( Co-PI ), R Kausar ( Co-PI ), E Anastasescu ( Lead Nurse ), K Reid ( Lead Nurse ), Ms. Jacqui.
Rotherham General Hospital, Rotherham, UK
A Hormis ( PI ), R Walker ( Lead Nurse ), D Collier.
North Manchester General Hospital, Manchester, UK
T Duncan ( PI ), A Uriel ( Co-PI ), A Ustianowski ( Co-PI ), H T-Michael ( Lead Nurse ), M Bruce, K Connolly, K Smith.
Basingstoke and North Hampshire Hospital, Basingstoke, UK
R Partridge ( PI ), D Griffin, M McDonald, N Muchenje.
Royal Free Hospital, London, UK
D Martin ( PI ), H Filipe ( Lead Nurse ), C Eastgate, C Jackson.
Hull Royal Infirmary, Hull, UK
A Gratrix ( PI ), L Foster, V Martinson, E Stones, Caroline Abernathy, P Parkinson.
Harefield Hospital, London, UK
A Reed ( PI ), C Prendergast ( Lead Nurse ), P Rogers, M Woodruff, R Shokkar, S Kaul, A Barron, C Collins.
Chesterfield Royal Hospital Foundation Trust, Chesterfield, UK
S Beavis( PI ), A Whileman ( Lead Nurse ), K Dale, J Hawes, K Pritchard, R Gascoyne, L Stevenson.
Barnet Hospital, London, UK
R Jha ( PI ), L Lim ( Lead Nurse ), V Krishnamurthy.
Aintree University Hospital, Liverpool, UK
R Parker ( PI ), I Turner-Bone ( Lead Nurse ), L Wilding, A Reddy.
St James’s University Hospital and Leeds General Infirmary, Leeds, UK
S Whiteley ( PI ), E Wilby ( Lead Nurse ), C Howcroft, A Aspinwall, S Charlton, B Ogg.
Glan Clwyd Hospital, Bodelwyddan, UK
D Menzies ( PI ), R Pugh ( Co-PI ), E Allan ( Lead Nurse ), R Lean, F Davies, J Easton, X Qiu, S Kumar, K Darlington.
University Hospital Crosshouse, Kilmarnock, UK
G Houston ( PI ), P O’Brien, T Geary, J Allan, A Meikle.
Royal Bolton Hospital, Bolton, UK
G Hughes ( PI ), M Balasubramaniam ( Co-PI ), S Latham ( Lead Nurse ), E McKenna ( Lead Nurse ), R Flanagan.
Princess of Wales Hospital, Llantrisant, UK
S Sathe ( PI ), E Davies, L Roche.
Pilgrim Hospital, Lincoln, UK
M Chablani ( PI ), A Kirkby, K Netherton, S Archer.
Northumbria Healthcare NHS Foundation Trust, North Shields, UK
B Yates ( PI ), C Ashbrook-Raby.
Ninewells Hospital, Dundee, UK
S Cole ( PI ), M Casey ( Co-PI ), L Cabrelli ( Lead Nurse ), S Chapman, M Casey, P Austin, A Hutcheon, C Whyte, C Almaden- Boyle.
Lister Hospital, Stevenage, UK
N Pattison ( PI ), C Cruz ( Lead Nurse ).
Bedford Hospital, Bedford, UK
A Vochin ( PI ), H Kent, A Thomas, S Murdoch ( Co-PI ), B David ( Lead Nurse ), M Penacerrada, G Lubimbi, V Bastion, R Wulandari, J Valentine, D Clarke.
Royal United Hospital, Bath, UK
A Serrano-Ruiz ( PI ), S Hierons ( Lead Nurse ), L Ramos, C Demetriou, S Mitchard, K White.
Royal Bournemouth Hospital, Bournemouth, UK
N White ( PI ), S Pitts ( Lead Nurse ), D Branney ( Lead Nurse ), J Frankham.
The Great Western Hospital, Swindon, UK
M Watters ( PI ), H Langton ( Lead Nurse ), R Prout.
Watford General Hospital, Watford, UK
V Page ( PI ), T Varghes.
University Hospital North Durham, Darlington, UK
A Cowton ( PI ), A Kay ( Lead Nurse ), K Potts, M Birt, M Kent, A Wilkinson.
Tameside General Hospital, Ashton Under Lyne, UK
E Jude ( PI ), V Turner ( Lead Nurse ), H Savill, J McCormick, M Clark, M Coulding, S Siddiqui, O Mercer, H Rehman, D Potla.
Princess Royal Hospital Shrewsbury and Royal Shrewsbury Hospital,
Shrewsbury, UK
N Capps ( PI ), D Donaldson ( Lead Nurse ), J Jones, H Button, T Martin, K Hard, A Agasou, L Tonks, T Arden, P Boyle, M Carnahan, J Strickley, C Adams, D Childs, R Rikunenko, M Leigh, M Breekes, R Wilcox, A Bowes, H Tiveran, F Hurford, J Summers, A Carter, Y Hussain, L Ting, A Javaid, N Motherwell, H Moore, H Millward, S Jose, N Schunki, A Noakes, C Clulow.
Arrowe Park Hospital, Wirral, UK
G Sadera ( PI ), R Jacob, C Jones.
The Queen Elizabeth Hospital, King’s Lynn, UK
M Blunt ( PI ), Z Coton ( Lead Nurse ), H Curgenven’, S Mohamed Ally, K Beaumont, M Elsaadany, K Fernandes, I Ali Mohamed Ali, H Rangarajan, V Sarathy, S Selvanayagam, D Vedage, M White.
Royal Blackburn Teaching Hospital, Blackburn, UK
M Smith ( PI ), N Truman ( Co-PI ), S Chukkambotla ( Co-PI ), S Keith ( Lead Nurse ), J Cockerill-Taylor ( Lead Nurse ), J Ryan-Smith, R Bolton, P Springle, J Dykes, J Thomas, M Khan, M T Hijazi, E Massey, G Croston.
Poole Hospital, Poole, UK
H Reschreite r( PI ), J Camsooksai( Lead Nurse ), S Patch, S Jenkins, C Humphrey, B Wadams, J Camsooksai.
Medway Maritime Hospital, Gillingham, UK
N Bhatia ( PI ), M Msiska ( Lead Nurse ), O Adanini.
Warwick Hospital, Warwick, UK
B Attwood ( PI ), P Parsons ( Lead Nurse ).
The Royal Marsden Hospital, London, UK
K Tatham ( PI ), S Jhanji ( Co-PI ), E Black ( Lead Nurse ), A Dela Rosa, R Howle, B Thomas, T Bemand, R Raobaikady.
The Princess Alexandra Hospital, Harlow, UK
R Saha ( PI ), N Staines ( Lead Nurse ), A Daniel, J Finn.
Musgrove Park Hospital, Taunton, UK
J Hutter ( PI ), P Doble ( Lead Nurse ), C Shovelton, C Pawley.
George Eliot Hospital NHS Trust, Nuneaton, UK
T Kannan ( PI ), M Hill.
East Surrey Hospital, Redhill, UK
E Combes ( PI ), S Monnery ( Co-PI ), T Joefield.
West Middlesex Hospital, Isleworth, UK
M Popescu ( PI ), M Thankachen, M Oblak.
Warrington General Hospital, Warrington, UK
J Little ( PI ), S McIvor, A Brady ( Co-PI ), H Whittle, H Prady, R Chan.
Southport and Formby District General Hospital, Ormskirk, UK
A Ahmed ( PI ), A Morris.
Royal Devon and Exeter Hospital, Exeter, UK
C Gibson ( PI ), E Gordon ( Lead Nurse ), S Keenan ( Lead Nurse ), H Quinn ( Lead Nurse ), S Benyon, S Marriott, L Zitter, L Park, K Baines.
Macclesfield District General Hospital, Macclesfield, UK
M Lyons ( PI ), M Holland ( Lead Nurse ), N Keenan ( Lead Nurse ), M Young.
Borders General Hospital, Melrose, UK
S Garrioch ( PI ), J Dawson ( Lead Nurse ), M Tolson.
Birmingham Children’s Hospital, Birmingham, UK
B Scholefield ( PI ), R Bi.
William Harvey Hospital, Ashford, UK
N Richardson ( PI ), N Schumacher ( Co-PI ), T Cosier, G Millen.
Royal Lancaster Infirmary, Lancaster, UK
A Higham ( PI ), K Simpson ( Lead Nurse ).
Queen Elizabeth the Queen Mother Hospital, Margate, UK
S Turki( PI ), L Allen ( Lead Nurse ), N Crisp ( Lead Nurse ), T Hazleton, A Knight, J Deery, C Price, S Turney, S Tilbey, E Beranova.
Liverpool Heart and Chest Hospital, Liverpool, UK
D Wright ( PI ), L Georg ( Lead Nurse ), S Twiss.
Darlington Memorial Hospital, Darlington, UK
A Cowton ( PI ), S Wadd ( Lead Nurse ), K Postlethwaite.
Southend University Hospital, Westcliff-on-Sea, UK
P Gondo ( PI ), B Masunda ( Lead Nurse ), A Kayani, B Hadebe.
Raigmore Hospital, Inverness, UK
J Whiteside ( PI ), R Campbell ( Lead Nurse ), N Clarke.
Salisbury District Hospital, Salisbury, UK
P Donnison ( PI ), F Trim, I Leadbitter.
Peterborough City Hospital, Peterborough, UK
D Butcher ( PI ), S O’Sullivan ( Lead Nurse ).
Ipswich Hospital, Ipswich, UK
B Purewal ( PI ), B Purewal ( Lead Nurse ), S Bell, V Rivers’.
Hereford County Hospital, Worcester, UK
R O’Leary( PI ), J Birch ( Lead Nurse ), E Collins ( Lead Nurse ), S Anderson ( Lead Nurse ), K Hammerton, E Andrews.
Furness General Hospital, Barrow-in-Furness, UK
A Higham ( PI ), K Burns ( Lead Nurse ).
Forth Valley Royal Hospital, Falkirk, UK
I Edmond ( PI ), D Salutous ( Lead Nurse ), A Todd, J Donnachie, P Turner, L Prentice, L Symon, N Runciman, F Auld.
Torbay Hospital, Torquay, UK
M Halkes ( PI ), P Mercer ( Lead Nurse ), L Thornton.
St Mary’s Hospital, Newport, UK
G Debreceni ( PI ), J Wilkins, A Brown, V Crickmore.
Royal Manchester Children’s Hospital, Manchester, UK
G Subramanian ( PI ), R Marshall ( Lead Nurse ), C Jennings ( Lead Nurse ), M Latif, L Bunni.
Royal Cornwall Hospital, Truro, UK
M Spivey ( PI ), S Bean, K Burt.
Queen Elizabeth Hospital Gateshead, Gateshead, UK
V Linnett( PI ), J Ritzema ( Lead Nurse ), A Sanderson ( Lead Nurse ), W McCormick, M Bokhari.
Kent & Canterbury Hospital, Canterbury, UK
R Kapoor ( PI ), D Loader ( Lead Nurse ).
James Paget University Hospital NHS Trust, Great Yarmouth, UK
A Ayers ( PI ), W Harrison ( Lead Nurse ), J North.
Darent Valley Hospital, Dartford, UK
Z Belagodu ( PI ), R Parasomthy ( Co-PI ), O Olufuwa ( Lead Nurse ), A Gherman, B Fuller, C Stuart.
The Alexandra Hospital, Redditch and Worcester Royal Hospital,
Worcester, UK
O Kelsall ( PI ), C Davis ( Co-PI ), L Wild ( Lead Nurse ), H Wood, J Thrush, A Durie, K Austin’, K Archer, P Anderson, C Vigurs.
Ysbyty Gwynedd, Bangor, UK
C Thorpe ( PI ), A Thomas ( Lead Nurse ), E Knights, N Boyle, A Price.
Yeovil Hospital, Yeovil, UK
A Kubisz-Pudelko ( PI ), D Wood ( Lead Nurse ), A Lewis,S Board, L Pippard, J Perry, K Beesley.
University Hospital Hairmyres, East Kilbride, UK
A Rattray( PI ), M Taylor ( Lead Nurse ), E Lee, L Lennon, K Douglas, D Bell, R Boyle, L Glass, A Rattray’
Scunthorpe General Hospital, Scunthorpe, UK
M Nauman Akhtar ( PI ), K Dent ( Lead Nurse ), D Potoczna, S Pearson, E Horsley, S Spencer.
Princess Royal Hospital Brighton, West Sussex, UK
C Phillips ( PI ), D Mullan ( Lead Nurse ), D Skinner, J Gaylard, L Ortiz- Ruizdegordoa.
Lincoln County Hospital, Lincoln, UK
R Barber ( PI ), C Hewitt ( Lead Nurse ), A Hilldrith, S Shepardson, M Wills, K Jackson-Lawrence.
Homerton University Hospital, London, UK
A Gupta ( PI ), A Easthope ( Co-PI ), E Timlick ( Lead Nurse ), C Gorman.
Glangwili General Hospital, Camarthen, UK
I Otaha ( PI ), A Gales ( Co-PI ), S Coetzee ( Lead Nurse ), M Raj, M Peiu.
Ealing Hospital, Southall, UK
V Parris ( PI ), S Quaid ( Lead Nurse ), E Watson.
Scarborough General Hospital, Scarborough, UK
K Elliott ( PI ), J Mallinson ( Co-PI ), B Chandler, A Turnbull.
Royal Albert Edward Infirmary, Wigan, UK
A Quinn ( PI ), C Finch, C Holl, J Cooper, A Evans.
Queen Elizabeth Hospital, Woolwich, London, UK
W Khaliq ( PI ), A Collins( Lead Nurse ), E Treus Gude.
North Devon District Hospital, Barnstaple, UK
N Love ( PI ), L van Koutrik, J Hunt ( Lead Nurse ), D Kaye, E Fisher, A Brayne, V Tuckey, P Jackson, J Parkin.
National Hospital for Neurology and Neurosurgery, London, UK
D Brealey ( PI ), E Raith ( Co-PI ), A Tariq ( Lead Nurse ), H Houlden, A Tucci, J Hardy, E Moncur.
Eastbourne District General Hospital, East Sussex, UK and Conquest
Hospital, East Sussex, UK
J Highgate( PI ), A Cowley ( Lead Nurse ).
Diana Princess of Wales Hospital, Grimsby, UK
A Mitra ( PI ), R Stead ( Lead Nurse ), T Behan, C Burnett, M Newton, E Heeney, R Pollard, J Hatton.
The Christie NHS Foundation Trust, Manchester, UK
A Patel ( PI ), V Kasipandian ( Co-PI ), S Allibone ( Lead Nurse ), R M Genetu.
Prince Philip Hospital, Lianelli, UK
I Otahal ( PI ), L O’Brien ( Lead Nurse ), Z Omar, E Perkins, K Davies.
Prince Charles Hospital, Merthyr Tydfil, UK
D Tetla ( PI ), C Pothecary, B Deacon.
Golden Jubilee National Hospital, Clydebank, UK
B Shelley ( PI ), V Irvine ( Lead Nurse ).
Dorset County Hospital, Dorchester, UK
S Williams ( PI ), P Williams ( Lead Nurse ), J Birch, J Goodsell, R Tutton, L Bough, B Winter-Goodwin.
Calderdale Royal Hospital, Halifax, UK
R Kitson ( PI ), J Pinnell ( Co-PI ), A Wilson ( Lead Nurse ), T Nortcliffe, T Wood, M Home, K Holdroyd, M Robinson, KHanson, R Shaw, J Greig, M Brady, A Haigh, L Matupe, M Usher, S Mellor, S Dale, L Gledhill, L Shaw, G Turner, D Kelly, B Anwar, H Riley, H Sturgeon, A Ali, L Thomis, D Melia, A Dance, K Hanson,
West Suffolk Hospital, Suffolk, UK
S Humphreys ( PI ), I Frost, V Gopal, J Godden, A Holden, S Swann.
West Cumberland Hospital, Whitehaven, UK
T Smith ( PI ), M Clapham ( Lead Nurse ), U Poultney, R Harper, P Rice.
University Hospital Lewisham, London, UK
W Khaliq ( PI ), R Reece-Anthony ( Lead Nurse ), B Gurung.
St John’s Hospital Livingston, Livingston, UK
S Moultrie ( PI ), M Odam.
Sheffield Children’s Hospital, Sheffield, UK
A Mayer ( PI ), A Bellini ( Lead Nurse ), A Pickard, J Bryant, N Roe, J Sowter.
Hinchingbrooke Hospital, Huntingdon, UK
D Butcher ( PI ), K Lang, J Taylor.
Glenfield Hospital, Leicester, UK
P Barry ( PI ).
Bronglais General Hospital, Aberystwyth, UK
M Hobrok ( PI ), H Tench ( Lead Nurse ), R Wolf-Roberts, H McGuinness, R Loosley.
Alder Hey Children’s Hospital, Liverpool, UK
D Hawcutt ( PI ), L Rad, L O’Malley, ( Lead Nurse ), P Saunderson, G Seddon, T Anderson, N Rogers.
University Hospital Monklands, Airdrie, UK
J Ruddy ( PI ), Margaret H ( Lead Nurse ), M Taylor ( Lead Nurse ), C Beith, A McAlpine, L Ferguson, P Grant, S MacFadyen, M McLaughlin, T Baird, S Rundell, L Glass, B Welsh, R Hamill, F Fisher.
Cumberland Infirmary, Carlisle, UK
T Smith ( PI ), J Gregory ( Lead Nurse ), A Brown.
Learning Model of Life
Ian Simpson, Mirella Lapata, Elham Kashefi, Filippo Menolascina, Sotirios Tsaftaris, Helen Hastie, David Brown, Jonathan Seckl, Konrad Rawlik, Mark Parsons, Sara Brown, Annis Richardson, Andrew Millar, Jane Hilston, Ava Khamseh, Kev Dhaliwal, Jonathan Millar, Marie Zechner, Charlie Gourlay, Mizeck Chagunda.
Funders
- Baillie Gifford
- Sepsis Research (Fiona Elizabeth Agnew Trust)
- UKRI
- Wellcome
- Intensive Care Society
RECOVERY
- Peter Horby, University of Oxford
- Martin Landray, University of Oxford
- Richard Haynes, University of Oxford
Baillie Gifford Pandemic Science Hub
- Kev Dhaliwal
Learning Model of Life
Ian Simpson, Mirella Lapata, Filippo Menolascina, Sotirios Tsaftaris, Helen Hastie, David Brown, Jonathan Seckl, Konrad Rawlik, Mark Parsons, Sara Brown, Annis Richardson, Andrew Millar, Jane Hilston, Ava Khamseh, Kev Dhaliwal, Jonathan Millar, Marie Zechner, Charlie Gourlay, Mizeck Chagunda.
GenOMICC Investigators
Erola Pairo-Castineira*, Sara Clohisey*, Lucija Klaric*, Andrew D. Bretherick*, Konrad Rawlik*, Dorota Pasko, Susan Walker, Nick Parkinson, Max Head Fourman, Clark D. Russell, James Furniss, Anne Richmond, Elvina Gountouna, Nicola Wrobel, David Harrison, Bo Wang, Yang Wu, Alison Meynert, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Loukas Moutsianas, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Graeme Grimes, Rupert Beale, Jonathan Millar, Barbara Shih, Sean Keating, Marie Zechner, Chris Haley, David J. Porteous, Caroline Hayward, Jian Yang, Julian Knight, Charlotte Summers, Manu Shankar-Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Shona C. Moore, Charles Hinds, Peter Horby, Alistair Nichol, David Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, Timothy Walsh, Alex Pereira, Alessandra Renieri, The GenOMICC Investigators, The ISARIC4C Investigators, The COVID-19 Human Genetics Initiative, 23andMe Investigators, BRACOVID Investigators, Gen-COVID Investigators, Xia Shen, Chris P. Ponting, Angie Fawkes, Albert Tenesa, Mark Caulfield, Richard Scott, Kathy Rowan, Lee Murphy, Peter J. M. Openshaw, Malcolm G. Semple, Andrew Law, Veronique Vitart, James F. Wilson & J. Kenneth Baillie.
Acknowledgements
Edinburgh Molecular Mechanisms Cluster
Deputy CIs:
- Konrad Rawlik (ECR) - Work Package: Machine learning
- Sara Clohisey Hendry (ECR) - Work Package: Tissues
Core staff:
- Max Pickup (ECR)
- Lizzie Lake (ECR)
Project Manager:
- Wilna Oosthuyzen
Co-Investigators:
- Johnny Millar (ECR) - Tissue lead: Lung
- Zoeb Jiwaji (ECR) - Tissue lead: Brain
- Sara Brown - Tissue lead: Skin
- Simon Biddie (ECR) - Tissue lead: Blood
- Erola Pairo-Casteneira (ECR)
- Andy Bretherick (ECR)
- Kev Dhaliwal
- Paul Brennan
- Andrew McIntosh
- Eleanor Earp (ECR)
Chloroform
Diethyl Ether
Methoxyflurane
Enflurane
Desflurane
Sevoflurane
Propofol
Nitrogen
GABAA Receptor
AI - causal inference
AI - causal inference
AI - DNA as a language
Explaining GWAS hits
molQTL
Brain
Lung
Systematic perturbation
Systematic perturbation
26,095
patients recruited
Aggregate variant testing
HLA-DRB1*04:01
Cases: 25/27 (92.6%)
Controls: 10/64 (15.6%)
OR = 112.3 (26.6–474.5)
P = 3.27 × 10−23
Kenneth Baillie
Kenny is Professor of Experimental Medicine, Co-director of the Baillie Gifford Pandemic Science Hub, and a consultant in critical care medicine at the Royal Infirmary, Edinburgh. He graduated from the University of Edinburgh in Physiology in 1999 and Medicine in 2002. He completed a PhD in statistical genetics before completing clinical training in intensive care medicine in 2014. After a period at the Broad Institute of Harvard and MIT, he returned to Edinburgh to establish a research programme using computational analyses of the human genome to understand and treat life-threatening infections. His discovery of a new genetic mechanism in Covid-19 led directly to an effective new treatment for the disease. He has been recognised with fellowship of the Royal Society of Edinburgh and the Academy of Medical Sciences, and is among the top 0.1% most highly-cited researchers worldwide across fields.
Ian Simpson
Mirella Lapata
Mirella is professor of natural language processing in the School of Informatics at the University of Edinburgh. Her research focuses on getting computers to understand, reason with, and generate natural language. She is the first recipient (2009) of the British Computer Society and Information Retrieval Specialist Group (BCS/IRSG) Karen Sparck Jones award and a Fellow of the Royal Society of Edinburgh, the ACL, and Academia Europaea.
Mirella has also received best paper awards in leading NLP conferences and has served on the editorial boards of the Journal of Artificial Intelligence Research, the Transactions of the ACL, and Computational Linguistics. She was president of SIGDAT (the group that organizes EMNLP) in 2018. She has been awarded an ERC consolidator grant, a Royal Society Wolfson Research Merit Award, and a UKRI Turing AI World-Leading Researcher Fellowship.
Filippo Menolascina
Filippo is the Director of Research at the Bayes Centre, the Innovation Hub for Artificial Intelligence and Data Science of the University of Edinburgh. A pioneer of the field of “Cybergenetics”, the discipline at the interface of Machine Learning, Control Engineering and Synthetic Biology that seeks to model and control cellular dynamics, his group studies innovative foundation models for time series analysis and dynamical systems modelling. A former UKRI Innovation Fellow, his contribution to broader society spans the areas of fundamental research, entrepreneurship and policy. Filippo, a computer engineer by trade, holds a MBA in Finance and is a serial entrepreneur: over the past decade he founded or co-founded four new ventures and exited one. Leveraging his experience, he now acts as Board Member/Observer for startups/spin-outs in the UK and US and as Advisor for Venture Capital firms; he previously served as Investment Executive for Old College Capital, the Venture Capital arm of the University of Edinburgh, and Scientist in Residence for Equity Gap, one of the largest and most active Business Angels groups in the UK.