Molecular Mechanisms Cluster

Functional Genomics meeting, Oxford

Kenny Baillie

2025-03-25

Number of letters: 1

Possible combinations: 4

Pairo-Castineira E, Clohisey S, Klaric L, Bretherick A, Rawlik K et al. Nature 2020

Pairo-Castineira E, Clohisey S, Klaric L, Bretherick A, Rawlik K et al. Nature 2020

RECOVERY Collaborative Group et al. medRxiv, March 2022

Explaining GWAS hits

molQTL

Brain

Lung

Systematic perturbation

Systematic perturbation

Single metric of success/failure

  • GWAS hits explained*

(* Absolute number of significant, replicated genome-wide associations with common disease in humans that significantly co-localise with a molQTL identified by our study)

Acknowledgements

Edinburgh Molecular Mechanisms Cluster

Deputy CIs:

  • Konrad Rawlik (ECR) - Work Package: Machine learning
  • Sara Clohisey Hendry (ECR) - Work Package: Tissues

Core staff:

  • Max Pickup (ECR)
  • Lizzie Lake (ECR)

Project Manager:

  • Wilna Oosthuyzen

Co-Investigators:

  • Johnny Millar (ECR) - Tissue lead: Lung
  • Zoeb Jiwaji (ECR) - Tissue lead: Brain
  • Sara Brown - Tissue lead: Skin
  • Simon Biddie (ECR) - Tissue lead: Blood
  • Erola Pairo-Casteneira (ECR)
  • Andy Bretherick (ECR)
  • Kev Dhaliwal
  • Paul Brennan
  • Andrew McIntosh
  • Eleanor Earp (ECR)